Table of Contents
Is alpha or beta thalassemia worse?
Alpha thalassemia major with hemoglobin Bart’s usually results in fatal hydrops fetalis. Beta thalassemia major causes hemolytic anemia, poor growth, and skeletal abnormalities during infancy. Affected children will require regular lifelong blood transfusions.
Is Alpha thalassemia a disability?
Alpha thalassemia/intellectual disability chromosome 16 (ATR-16) syndrome is an extremely rare disorder characterized by intellectual disability, which is milder than in ATR-X syndrome, and alpha thalassemia, which is more severe than in ATR-X syndrome.
Can I donate blood if I have alpha thalassemia trait?
Persons with thalassemia minor (thalassemia carriers or thalassemia trait) can donate blood, if they meet the required criterias. The blood tests done before blood transfusion are necessary to protect the health of both the donor and the recipient.
Can alpha thalassemia be cured?
This condition causes mild to severe anemia, based on the type of alpha thalassemia that is inherited. People who have this condition can pass the disease on to their children. There is no cure. Treatment can reduce symptoms.
Are people with alpha thalassemia immunocompromised?
Because of this, people with thalassemia are said to be “immunocompromised,” which means that some of the body’s defenses against infection aren’t working.
What is the treatment for alpha thalassemia minor?
Currently, the only cure for thalassemia is a procedure called a bone marrow transplant (also called a stem cell transplant). Bone marrow, which is found inside bones, produces blood cells. In a bone marrow transplant, a person is first given high doses of radiation or drugs to destroy the defective bone marrow.
Is thalassemia a serious disease?
Life expectancy. Thalassemia is a serious illness that can lead to life-threatening complications when left untreated or undertreated.
What part of the body does thalassemia affect?
The spleen helps your body fight infection and filter unwanted material, such as old or damaged blood cells. Thalassemia is often accompanied by the destruction of a large number of red blood cells. This causes your spleen to enlarge and work harder than normal.
Is thalassemia linked to leukemia?
Abstract. Occurrence of leukemia in thalassemia major is a rare presentation. Here we report two cases of thalassemic patients, developing acute lymphoblastic leukemia. The genetic analysis revealed that, female and male patients were homozygous for IVSI-6 and IVSI-5, respectively.
Can you get pregnant if you have thalassemia?
Thalassemia in pregnancy Women with thalassemia who require blood transfusions often have a higher rate of infertility. However, some women with the disease are able to become pregnant.
Who is most likely to thalassemia?
People who have family members from certain parts of the world have a higher risk for having thalassemia. Traits for thalassemia are more common in people from Mediterranean countries, like Greece and Turkey, and in people from Asia, Africa, and the Middle East.
Can thalassemia show up later in life?
When the disorder develops later during life, a diagnosis of beta thalassemia intermedia is given; individuals may only require blood transfusions on rare, specific instances.
Is thalassemia an autoimmune disease?
It was generally assumed that the β-thalassemia heterozygotes do not bear significant medical risks except a mild microcytic anemia. Nonetheless, increasing number of reports associate β-thalassemia trait with autoimmune conditions, nephritis, diabetes, arthritis, fibromyalgia and asthma.
How can a blood test detect thalassemia?
Several laboratory tests may be used to help detect and diagnose thalassemia:
- Complete blood count (CBC). The CBC is an evaluation of the cells in the blood.
- Blood smear (also called peripheral smear and manual differential).
- Iron studies.
- Hemoglobinopathy (Hb) evaluation (hemoglobin electrophoresis).
Can thalassemia major Be Cured?
Blood transfusions and chelation do not cure beta thalassemia. A stem cell transplant can cure it, but it is a serious procedure with many risks and won’t benefit everyone with the condition. Doctors and scientist are working on developing gene therapies and other treatments to help people with beta thalassemia.
How is thalassemia major diagnosed?
If your doctor suspects your child has thalassemia, he or she can confirm a diagnosis with blood tests. Blood tests can reveal the number of red blood cells and abnormalities in size, shape or color. Blood tests can also be used for DNA analysis to look for mutated genes.
How can you tell the difference between iron deficiency and thalassemia?
The two best measures or calculations from the CBC are the Red Blood Cell count alone (RBC) and the Mentzer Index (MCV/RBC). An RBC above 5 x 1012/l is often seen in thalassemia, while a count <5 is more typical of iron deficiency.
Is thalassemia related to iron deficiency?
It has long been considered that iron deficiency does not exist in thalassemia syndromes, including thalassemia major as well as trait. However, studies have shown the occurrence of iron deficiency in patients with beta thalassemia trait (BTT).
Can thalassemia be misdiagnosed?
It is commonly misdiagnosed and treated for iron deficiency. If unusually high plasma iron or serum ferritin is encountered in beta thalassemia trait one should rule out coexisting hemochromatosis or iron supplementation. Women carriers can develop moderately severe anemia during pregnancy.
Can thalassemia patients take iron?
People with thalassemia trait should not take iron supplementation, as this will not improve your anemia.
Is beta thalassemia minor a disability?
The RPWD Act 2016 has recognised persons with blood disorders (Thalassemia, Hemophilia and Sickle Cell Disease) as ‘persons with disabilities’ under the Act. Those with 40% and above disability will be given a Disability Certificate.
Can thalassemia minor patients take iron?
If you have thalassemia trait, your physician may prescribe iron supplements because your red blood cells are smaller than is typical. Unless you also have iron deficiency in addition to thalassemia, this is not needed and should be avoided.
What should be avoided in thalassemia minor?
Nutritional deficiencies are common in thalassemia. It is recommended that patients going through blood transfusion should opt for a low iron diet. Avoiding iron-fortified foods like cereal, red meat, green leafy vegetables & Vitamin C-rich foods is the best option for thalassemic patients.